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Professor & HoD Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (Constituent College, JSS Academy of Higher Education &Research-Deemed to be University, Mysuru) Ooty-643 001, The Nilgiris, Tamilnadu,INDIA The author has about 23 years of teaching and research experience. The Author has more than 110 research publications in reputed National and International journals and has H-index 16 by scopus. He has also published 9 books. He is a recognized research guide for Ph.D in JSS Academy of Health Education and Research and He served as editorial member and reviewer in many reputed National and International journals. He is the winner in Drug Discovery Hackathon-2020 for Covid-19 Drug discovery organized by Govt of India and also received a Research grant of 14.35 lakhs in phase-II research. He is nominated as BOS member in various universities. He has organized many national and International seminar/ workshop/ Conferences etc sponsored by various funding agencies.

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Tuesday, April 2, 2019

Pharm.D_POC_Proteins_MCQ

Pharm.D_POC_Proteins_MCQ

1.How many amino acids are synthesized by our bodies?                                                     
a) 10                                                                                                                               
b) 20                                                                                                                               
c) 30                                                                                                                               
d) 40

2.Aminoacids has                                                                                                                                 
a) both amino group and carboxyl group                                                                                       
b) both amino group and keto group                                                                                           
c) amino group only                                                                                                                                  d) carboxyl group only

3.Sulphur containing amino acids are                                                                                                 
a) Cysteine and methionine                                                                                                                     b) Methionine and threonine                                                                                                           
c) Cysteine and threonine                                                                                                               
d) Cysteine and serine

4.Which is the most stable structural level for proteins
a) Primary structure
b) Secondary structure
c) Tertiary structure
d)Quaternary structure 

5.Which among the following is a simple protein
a) Glycoprotein
b) Chromoprotein
c) Albumin
d) Lipoprotein

6.Which of the following test is used to identify the sulphur containing amino acids
a) Lead-Sulfide test
b) Xanthoproteic test
c) Millons test
d) Ninhydring test

7.Which is a aromatic amino acid
a) Alanine
b) Serine
c) Glutamic acid
d) Tyrosine

8.Which is a aliphatic amino acid
a) Phenyl alanine
b) Tyrosine
c) Leucine 
d) Tryptophan

9.Which amino acid is essential only in child hood
a) Arginine
b) Alanine
c) Phenyl alanine
d) Tyrosine

10.Amino acids with hydroxyl groups are                                                                                   
a) serine and alanine                                                                                                                 
b) alanine and valine                                                                                                                         
c) serine and threonine                                                                                                                 
d) valine and isoleucine

Pharm.D_POC_Carbohydrates_MCQ

Pharm.D_POC_Carbohydrates_MCQ

1.Sucrose is a                                                                                                                                             a) monosaccharide                                                                                                                                 b) disaccharide                                                                                                                                          c) polysaccharide                                                                                                                                     d) triose

2.The general formula of carbohydrate is                                                                                   
a) (CH2O)n                                                                                                                                              b) (C4H2O)n                                                                                                                                              c) (C6H2O)n                                                                                                                                              d) (C2H2O)n COOH

3.Which of the following is NOT a disaccharide?                                                                     
a) Hyaluronic acid                                                                                                                             
b) Maltose                                                                                                                                                c) Lactose                                                                                                                                                  d) Sucrose 

4.Sucrose is composed of which two sugars?                                                                           
a) Glucose and Glucose                                                                                                             
b) Glucose and Fructose                                                                                                             
c) Glucose and Galactose                                                                                                                 
d) Fructose and Galactose

5.Which of the following is a carbohydrate with no nutritional value?                             
a) Glycogen                                                                                                                                         
b) Starch                                                                                                                                               
c) Dextrin                                                                                                                                                  d) Cellulose

6.Which of the following gives a brown colour on reaction with iodine?                                                a) Starch                                                                                                                                                    b) Glycogen                                                                                                                                         
c) Dextrin                                                                                                                                                d) Cellulose

7.Which of the following is a test to differentiate mono sacharides from disaccharides
a) Seliwanofs test
b) Iodine test
c) Fehlings test
d) Barfoeds test

8.Which is a test for reducing sugars
a) Molisch test
b) Millons test
c) Tollens test
d) Iodine test

9.Which among the following test is a general test for carbohydrates
a) Biurette test
b) Urea nitrate test
c) Sakaguchi test
d) Molisch test

10.Which test distinguishes aldose from ketose
a) Molisch test
b) Barfoeds test
c)  Fehlings test
d) Seliwanofs test

Pharm.D_POC_Heterocyclic Compounds_MCQ

Pharm.D_POC_Heterocyclic Compounds_MCQ

1.The nitrogen atom in pyridine is                                                                                                     
a) sp3 hybridized                                                                                                                               
b) sp2 hybridized                                                                                                                                 
c) sp hybridized                                                                                                                                     
d) cannot be predicted

2.Which is the five membered heterocycle among the following
a) Pyridine
b) Piperazine
c) Pyridine
d) Pyrrole 

3.Which is the six membered heterocycle among the following
a) Pyrrole
b) Thiazole
c) Oxazole
d) Piperidine 

4.Furan contains which hetero atom
a) Oxygen
b) Nitrogen
c) Sulphur
d) Phosporus

4.Among the following heterocycle which is saturated
a) Pyrrole
b) Pyridine
c) Pyrrolidine 
d) 2-Pyrroline

5.Which is made of bicyclic ring system
a) Indole
b) Pyridine
c) Pyrrolidine
d) 2-Pyrroline 

Monday, April 1, 2019

Pharm.D_POC_Phenols_MCQ

Pharm.D_POC_Phenols_MCQ

1.Phenol is acidic because of
A) Resonance     
B) Electrometric effect
C) Inductive effect   
D) peroxide effect

2.Phenol upon Friedel-Crafts methylation gives
A) Cresol     
B) Salicylic acid
C) Xylene     
D) Resorcinol

3.Phenols are
a) acidic in nature
b) basic in nature
c) neutral in nature
d) Amphoteric in nature

4.The major product obtained on interaction of phenol with sodium hydroxide and carbon dioxide is
a) benzoic acid
b) salicylaldehyde
c) salicylic acid
d) phthalic acid

5.lectrophilic substitution reaction in phenol generally occurs at
a) ortho and para position
b) only ortho position
c) only para position
d) metaposition

6.Phenol on heating with phthalic anhydride in the presence of concentrated sulfuric acid gives
a) phenolphthalein
b) bakelite
c) salicylic acid
d) fluorescine

7.The Reimer-Tiemann reaction is used to convert a phenol to an
a) p-hydroxy benzaldehyde
b) o-hydroxy benzaldehyde
c) m-hydroxy benzaldehyde
d) o,p-dihdroxy benzaldehyde

Pharm.D_POC_Amines_MCQ

Pharm.D_POC_Amines_MCQ

1.Reaction by which Diazonium salts are obtained from primary aromatic amines by treating with NaNO2 and HCl at 0-50C is known as
A) Coupling reaction     
B) Sandmayer’s reaction
C) Diazotization reaction   
D) Claisen Condensation

2.The hybridization of nitrogen in an amine is                                                                         
a) sp                                                                                                                                                     
b) sp3                                                                                                                                               
c) sp2                                                                                                                                                   
d) sp4

3.Amines are generally classified as                                                                                             
a) Weak acids                                                                                                                                     
b) Strong acids                                                                                                                                   
c) Weak bases                                                                                                                                 
d) Strong bases

4.Which of the following amine is more basic
a) Ammonia
b) Methyl amine
c) NN-Dimethyl amine
d) Trimethyl amine

5.Aromatic amine are
a) Slightly acidic in nature
b) Strong bases than mineral bases
c) More basic than aliphatic amines
d) Less basic than aliphatic amines

6.Electron releasing groups
a) increases the basicity of amines
b) decreases the basicity of amines
c) it has no effect on the basicity of amines
d) decreases the resonance stabilization of amines 

7.Amines are?
a) sp2 hybridized nitrogen compounds
b) weakly acidic
c) electrophilic
d) have a pyramidal arrangement of bonds

8.Which of the following compound gives azo dye test
 (a) aniline
 (b) methylamine
 (c) diphenylamine
 (d) ethylamine

9.Amines behave as
 (a) lewis acids
 (b) lewis bases
 (c) aprotic acids
 (d) amphoteric compounds

10.Which of the following is an primary amine
a) diphenyl amine
b) triphenyl amine
c) aniline
d) N,N-dimethylaniline

11.What is the acid liberated in situ during diazotisation reaction
a) Hydrochloric acid 
b) Sulphuric acid
c) Nitrous acid 
d) Nitric acid

12.Hoffmann bromide degradation is shown by
a) ArNH2
b) ArCONH2
c) ArNO2
d) ArCH2NH2

Pharm.D_POC_Carboxylicacid Derivatives_MCQ

Pharm.D_POC_Carboxylicacid Derivatives_MCQ

1.The characteristic reactions of carboxylic acids is
A)  Electrophilic addition   
B) Electrophilic substitution
C) Nucleophilic addition   
D) Nucleophilc substitution.

2.Conversion of a carboxylic acid to an ester is known as
 A) Reduction     
 B) Oxidation
 C) Esterification     
 D) Polymerization

3.  The products of the reaction of a carboxylic acid and an alcohol would be
 A) Ketone & water     
 B) Amide & water
 C) Acid chloride & water   
 D) Ester & water

4.Carboxylic acid can be prepared by
A) Hydrolysis of nitriles   
B) Hydrolysis of esters 
C) Oxidation of Aldehydes 
D) All the above

5.The presence of electron-releasing alkyl groups in carboxylic acid -------- the acidity.
A) Increase   
B) Decrease 
C) Neutralize   
D) No change

6.Which of the following carboxylic acid is more acidic.
A) Formic acid   
B) Acetic acid 
C) Propionic acid   
D) Butanoic acid

7.One of the following is not a carboxylic acid derivative
A) Esters       
B) Amides 
C) Aldehydes     
D) Anhydrides

8.An ether is more volatile than an alcohol having the same molecular formula. This is due to 
A) dipolar character of ethers   
B) alcohols having resonance structures
C) inter-molecular hydrogen bonding in ethers
D) inter-molecular hydrogen bonding in alcohols

9.Among the following carboxylic acids which is more acidic 
a) Chloro acetic acid 
b) Fluoro acetic acid 
c)  Bromo acetic acid 
d) Iodo acetic acid 

10.Among the following carboxylic acids which is more acidic 
a) Acetic acid 
b) Chloro acetic acid 
c) Dichloro acetic acid  
d) Trichloro acetic acid   

11.Which among the following is not a functional derivative of carboxylic acid 
a) Amide
b) Ester
c) Anhydride 
d) Amine

12.Carboxylate ion stabilises via 
a) Inductive effect 
b) Electromeric effect
c) Resonance effect 
d) Hyperconjugation effect 


Pharm.D_POC_Carbonyl Compounds_MCQ

Pharm.D_POC_Carbonyl Compounds_MCQ

1.Cannizaro reaction is not given by
A) Formaldehyde   
B) Trimethyl acetaldehyde 
C) Acetaldehyde     
D) Benzaldehyde

2.Aldehydes having no α-hydrogen atoms undergo
A) Tishenko reaction   
B) Reimer Tiemann reaction
C) Cannizaro reaction 
D) Rosenmund reaction

3.Conversion of a carboxylic acid to an ester is known as
A) Reduction     
B) Oxidation
C) Esterification     
D) Polymerization

4.Conversion of an aldehyde to an alcohol is generally known as
 A) Reduction     
 B) oxidation
 C) Esterification     
 D) substitution

5.Which class of compound is an example of a carbonyl compound?
A) Alcohol   
B) Carboxylic acid
C) Alkene   
D) Alkane

6.Which molecule is an example of a ketone?
A) Ethanal   
B) Ethanoic anhydride
C) Propan-2-one    
D) Propanamide

7.Which of the following alcohols forms a ketone when oxidized?
A) 1-propanol   
B) methanol
C) 2-methyl-2-propanol 
D) 2-propanol

8.Clemmensen reduction of a ketone is carried out in the presence of which of the following?
A) H2 and Pt as catalyst   
B) Glycol with KOH
C) Zn-Hg with HCl   
D) LiAlH4

9.Which of the following compound undergos condensation reaction
 (a) Ether
 (b) Alkene
 (c) Alkene
 (d) Aldehyde

10.Aldehydes that contain alpha hydrogens undergos
 (a) Cannizzaros reaction
 (b) Aldol condensation 
 (c)  Benzoin condensation
 (d) Perkin condensation

11.Aldehydes that do not contain alpha hydrogens undergos
 (a) Perkin condensation
 (b) Aldol condensation
 (c)  Crossed aldol condensation
 (d) Cannizzaros reaction

12.Which of the following aldehyde participates in Perkin condensation
(a) Acetaldehyde
 (b) Propanaldehyde
 (c)  Butaraldehyde
 (d) Benzaldehyde 

13.Benzoin condensation proceeds in the presence of
a) Alcoholic KOH
b) Aqueous KOH
c) Alcoholic KCN
d)Alcoholic K2CO3

14.Which of the following intermediate is formed during aldol condensation mechanism
a) Free radical
b) Carbanion 
c) Carbocation
d) Carbene

15.What is the product formed when a ketone reacts with hydroxyl amine
a) Imine
b) Schiffs base
c) Oxime
d) Aldol

16.Which of the following likely to be a product of Perkin condensation
a) Formic acid
b) Acetic acid
c) Cinnamic acid
d) Benzoic acid

Organic Intermediates- Nitrenes