POC-I Syllabus

BP202T. PHARMACEUTICAL ORGANIC CHEMISTRY –I (Theory)

                                                                                                            45 Hours

Scope: This subject deals with classification and nomenclature of simple organic compounds, structural isomerism, intermediates forming in reactions, important physical properties, reactions and methods of preparation of these compounds. The syllabus also emphasizes on mechanisms and orientation of reactions.

Objectives: Upon completion of the course the student shall be able to

1.     write the structure, name and the type of isomerism of the organic compound

2.     write the reaction, name the reaction and orientation of reactions

3.     account for reactivity/stability of compounds,

4.     identify/confirm the identification of organic compound

Course Content:

·       General methods of preparation and reactions of compounds superscripted with asterisk (*) to be explained ·       To emphasize on definition, types, classification, principles/mechanisms, applications, examples and differences

UNIT-I                                                                                                                                    10 Hours ·       Alkanes*, Alkenes* and Conjugated dienes* a.      SP3 hybridization in alkanes, Halogenation of alkanes, uses of paraffins. b.     Stabilities of alkenes, SP2 hybridization in alkenes E1 and E2 reactions – kinetics, order of reactivity of alkyl halides, rearrangement of carbocations, Saytzeffs orientation and evidences.  E1 verses E2 reactions, Factors affecting E1 and E2 reactions. Ozonolysis, electrophilic addition reactions of alkenes, Markownikoff’s orientation, free radical addition reactions of alkenes, Anti Markownikoff’s orientation. Stability of conjugated dienes, Diel-Alder, electrophilic addition, free radical addition reactions of conjugated dienes, allylic rearrangement

UNIT-II                                                                                                                                    10 Hours ·       Alkyl halides* a.      SN1 and SN2 reactions - kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations. b.     SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions c.      Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene, dichloromethane, tetrachloromethane and iodoform. ·       Alcohols*- Qualitative tests, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosteryl alcohol, Benzyl alcohol, Glycerol, Propylene glycol

UNIT-III                                                                                                                                  10 Hours ·       Carbonyl compounds* (Aldehydes and ketones) Electromeric effect, aldol condensation, Crossed Aldol condensation, Cannizzaro reaction, Crossed Cannizzaro reaction, Benzoin condensation, Perkin condensation, qualitative tests, Structure and uses of Formaldehyde, Paraldehyde, Acetone, Chloral hydrate, Hexamine, Benzaldehyde, Vanilin, Cinnamaldehyde.

UNIT-IV                                                                                                                                   08 Hours ·       Carboxylic acids* a.     Acidity of carboxylic acids, effect of substituents on acidity, inductive effect and qualitative tests for  carboxylic acids amide and ester b.     Structure and Uses of Acetic acid, Lactic acid, Tartaric acid, Citric acid, Succinic acid. Oxalic acid, Salicylic acid, Benzoic acid, Benzyl benzoate, Dimethyl phthalate, Methyl salicylate and Acetyl salicylic acid ·       Aliphatic amines* - Basicity, effect of substituent on Basicity. Qualitative test, Structure and uses of Ethanolamine, Ethylenediamine, Amphetamine

UNIT-V                                                                                                                                    07 Hours ·       Classification, nomenclature and isomerism a.      Classification of Organic Compounds b.     Common and IUPAC systems of nomenclature of organic compounds (up to 10 Carbons open chain and carbocyclic compounds) c.      Structural isomerisms in organic compounds

BP208P. PHARMACEUTICAL ORGANIC CHEMISTRY -I (Practical)

4 Hours / week

1	Systematic qualitative analysis of unknown organic compound/s for preliminary tests
2	Systematic qualitative analysis of unknown organic compound/s for preliminary and Lassaigns tests.
3	Systematic qualitative analysis of unknown organic compound/s for functional group (for preliminary / Lassaigns / solubility / functional group tests ) Following classes of compounds may be analyzed Phenols, amide/ urea, carbohydrate, amine, carboxylic acid, aldehyde, ketone, alcohol, carboxylic acid ester, hydrocarbon, halohydrocarbon, nitro compound and anilide
4	Determination of melting and boiling points of organic compounds
5	Systematic qualitative analysis of unknown organic compound for functional group and identification of the organic compound
6	Preparation of suitable solid derivatives from organic compounds
7	Systematic qualitative analysis of unknown organic compound for Functional group, its identification and confirmation of identification
8	Construction of molecular models

Recommended Books (Latest Editions)

1.     Organic Chemistry by Morrison and Boyd

2.     Organic Chemistry by I.L. Finar , Volume-I

3.     Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.

4.     Organic Chemistry by P.L.Soni

5.     Practical Organic Chemistry by Mann and Saunders.

6.     Vogel’s text book of Practical Organic Chemistry

7.     Advanced Practical organic chemistry by N.K.Vishnoi.

Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.