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Professor & HoD Department of Pharmaceutical Chemistry, JSS College of Pharmacy, (Constituent College, JSS Academy of Higher Education &Research-Deemed to be University, Mysuru) Ooty-643 001, The Nilgiris, Tamilnadu,INDIA The author has about 23 years of teaching and research experience. The Author has more than 110 research publications in reputed National and International journals and has H-index 16 by scopus. He has also published 9 books. He is a recognized research guide for Ph.D in JSS Academy of Health Education and Research and He served as editorial member and reviewer in many reputed National and International journals. He is the winner in Drug Discovery Hackathon-2020 for Covid-19 Drug discovery organized by Govt of India and also received a Research grant of 14.35 lakhs in phase-II research. He is nominated as BOS member in various universities. He has organized many national and International seminar/ workshop/ Conferences etc sponsored by various funding agencies.

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Friday, August 24, 2018

Melting Point, Boiling point, Solubility


Boiling point
            The boiling point of an element or a substance is the temperature at which the vapor pressure of the liquid equals the environmental pressure surrounding the liquid.
             The boiling point of a liquid varies dependent upon the surrounding environmental pressure. Different liquids (at a given pressure) boil at different temperatures. A liquid in a vacuum environment has a lower boiling point than when the liquid is at atmospheric pressure. A liquid in a high pressure environment has a higher boiling point than when the liquid is at atmospheric pressure.
            The normal boiling point of a liquid is the special case in which the vapor pressure of the liquid equals the defined atmospheric pressure at sea level, 1 atmosphere. At that temperature, the vapor pressure of the liquid becomes sufficient to overcome atmospheric pressure and lift the liquid to form bubbles inside the bulk of the liquid. The standard boiling point is now defined by IUPAC as the temperature at which boiling occurs under a pressure of 1 bar.
            The heat of vaporization is the amount of energy required to convert or vaporize a saturated liquid (i.e., a liquid at its boiling point) into a vapor.
            Liquids may change to a vapor at temperatures below their boiling points through the process of evaporation. Evaporation is a surface phenomenon in which molecules located near the liquid's edge, not contained by enough liquid pressure on that side, escape into the surroundings as vapor. On the other hand, boiling is a process in which molecules anywhere in the liquid escape, resulting in the formation of vapor bubbles within the liquid.
Determination of Boiling Points
·  Boiling point is determined by Capillary tube method.
·  In this method, a few drops of  liquid are placed in a thin walled small test tube.
·  A capillary tube sealed at about 1 cm from one end, is dropped in to it.
·  A glass tube containing the liquid and capillary, is then tied along a side of thermometer so that the liquid stands just near the bulb.
·  The thermometer is then lowered in a beaker containing paraffin oil.
·  The beaker is heated and the bath liquid stirred continuously using with stirrer.
·  When the boiling point reached, bubbles come from lower end of capillary.
·  The read the temperature from thermometer when the evaluation of bubbles just stop.


Melting Point
            The melting point of a substance is the temperature at which the solid phase converts to the liquid phase under 1 atmosphere of pressure.
            The melting point is one of a number of physical properties of a substance that is useful for characterizing and identifying the substance.
            To measure the melting point of a substance, it is necessary somehow to gradually heat a small sample of the substance while monitoring its temperature with a thermometer. The temperature at which liquid is first seen is the lower end of the melting point range. The temperature at which the last solid disappears is the upper end of the melting point range. A pure substance normally has a melting point range no larger than 1-1.5 oC.
            Although many substances melt cleanly and can be melted, crystallized, and remelted repeatedly without chemical decomposition, others chemically decompose before they melt, forming substances of lower molecular weight.
            The temperature at which the color change is first observed signals that the substance is approaching the decomposition temperature.
Determination of Melting Points
·  Melting point is also determined by Capillary tube method.
· A glass capillary tube which is 5-6 cm long and 1mm diameter, normally used to contain the sample for a melting point determination.
·  The tube must have one open end into which the sample can be loaded, and one sealed end so that the capillary will retain the solid sample.
·  The substance should stand in the capillary 3-4 mm from the bottom when thoroughly packed.
· The capillary is wetted with liquid in the bath and then tied along a side of thermometer fixed in an iron stand.
· The thermometer is then lowered in a beaker containing paraffin oil.
· The beaker is heated and the bath liquid stirred continuously using with stirrer.
·  When the substance in the capillary just shows sign of melting , the burner is removed and stirring continued.
· The read the temperature from thermometer when the substance melts and become transparent. This is the melting point range of that substance.

Solubility

Ø  A solution is a homogeneous mixture of two or more substances.
Ø  A solute is defined as the substance that dissolves in a solution.
Ø  A solvent is defined as the material that dissolves the other substance(s) in a solution. It is the dissolving medium.
Ø  Solubility is defined as the maximum amount of a substance (solute) which will dissolve in a given amount of solvent at a specific temperature.
            Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a liquid or gaseous solvent to form a homogeneous solution of the solute in the solvent.
            The solubility of a substance depends on the used solvent as well as on temperature and pressure. The extent of the solubility of a substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase the concentration of the solution.
            The solvent is generally a liquid, which can be a pure substance or a mixture. The extent of solubility ranges widely, from infinitely soluble such as ethanol in water, to poorly soluble, such as silver chloride in water. The term insoluble is often applied to poorly or very poorly soluble compounds.
            Under certain conditions the equilibrium solubility can be exceeded to give a so-called supersaturated solution, which is metastable.
            According to an IUPAC definition, solubility is the analytical composition of a saturated solution expressed as a proportion of a designated solute in a designated solvent. Solubility may be stated in units of concentration, molality, mole fraction, mole ratio, and other units.

Factors affecting solubility

            The solubility of one substance in another is determined by the balance of intermolecular forces between the solvent and solute, and the entropy change that accompanies the solvation. Factors such as temperature and pressure will alter this balance, thus changing the solubility.
            Solubility may also strongly depend on the presence of other species dissolved in the solvent, for example, complex-forming anions (ligands) in liquids.
Solubility will also depend on the excess or deficiency of a common ion in the solution, a phenomenon known as the common-ion effect. Solubility will depend on the ionic strength of solutions.

Temperature

            The solubility of a given solute in a given solvent depends on temperature. For many solids dissolved in liquid water, the solubility increases with temperature up to 100 °C. In liquid water at high temperatures, the solubility of ionic solutes tends to decrease due to the change of properties and structure of liquid water; the lower dielectric constant results in a less polar solvent.
            The chart shows solubility curves for some typical solid inorganic salts (temperature is in degrees Celsius). Many salts behave like barium nitrate and disodium hydrogen arsenate, and show a large increase in solubility with temperature. Some solutes (e.g. NaCl in water) exhibit solubility which is fairly independent of temperature. A few, such as cerium(III) sulfate, become less soluble in water as temperature increases. This temperature dependence is sometimes referred to as "retrograde" or "inverse" solubility.
            The solubility of organic compounds nearly always increases with temperature. The technique of recrystallization, used for purification of solids, depends on a solute's different solubilities in hot and cold solvent. A few exceptions exist, such as certain cyclodextrins.

Pressure

            For condensed phases (solids and liquids), the pressure dependence of solubility is typically weak and usually neglected in practice. Assuming an ideal solution, the dependence can be quantified as:
            The pressure dependence of solubility does occasionally have practical significance. For example, precipitation fouling of oil fields and wells by calcium sulfate (which decreases its solubility with decreasing pressure) can result in decreased productivity with time.

 Polarity

            A very polar (hydrophilic) solute such as urea is very soluble in highly polar water, less soluble in fairly polar methanol, and practically insoluble in non-polar solvents such as benzene. In contrast, a non-polar or lipophilic solute such as naphthalene is insoluble in water, fairly soluble in methanol, and highly soluble in non-polar benzene.
            The solubility is favored by entropy of mixing and depends on enthalpy of dissolution and the hydrophobic effect.

 Applications

            Solubility is of fundamental importance in a large number of scientific disciplines and practical applications, ranging from ore processing, to the use of medicines, and the transport of pollutants.
            Solubility is often said to be one of the "characteristic properties of a substance," which means that solubility is commonly used to describe the substance, to indicate a substance's polarity, to help to distinguish it from other substances, and as a guide to applications of the substance. For example, indigo is described as "insoluble in water, alcohol, or ether but soluble in chloroform, nitrobenzene, or concentrated sulfuric acid".
            Solubility of a substance is useful when separating mixtures. For example, a mixture of salt (sodium chloride) and silica may be separated by dissolving the salt in water, and filtering off the un dissolved silica.
            Another example of this is the synthesis of benzoic acid from phenyl magnesium bromide and dry ice. Benzoic acid is more soluble in an organic solvent such as dichloromethane or diethyl ether, and when shaken with this organic solvent in a separatory funnel, will preferentially dissolve in the organic layer. The other reaction products, including the magnesium bromide, will remain in the aqueous layer, clearly showing that separation based on solubility is achieved. This process, known as liquid-liquid extraction, is an important technique in synthetic chemistry.

Solubility of ionic compounds in water

            Some ionic compounds (salts) dissolve in water, which arises because of the attraction between positive and negative charges. For example, the salt's positive ions (e.g. Ag+) attract the partially-negative oxygens in H2O. Likewise, the salt's negative ions (e.g. Cl) attract the partially-positive hydrogens in H2O.
AgCl(s) Ag+(aq) + Cl(aq)
However, there is a limit to how much salt can be dissolved in a given volume of water. This amount is given by the solubility product, Ksp. This value depends on the type of salt (AgCl vs. NaCl), temperature, and the common ion effect.

Solubility of organic compounds

            The principle of polarity, that like dissolves like, is the usual guide to solubility with organic systems. For example, petroleum jelly will dissolve in gasoline because both petroleum jelly and gasoline are non-polar hydrocarbons. It will not, dissolve in ethyl alcohol or water, since the polarity of these solvents is too high. Sugar will not dissolve in benzene, since sugar is too polar in comparison with benzene.

Solubility in non-aqueous solvents

            Non polar solutes are soluble in non aqueous solvents. Most available solubility values are those for solubility in water. The reference also lists some for non-aqueous solvents.

 Quantification of solubility

            Solubility is commonly expressed as a concentration, either by mass (g of solute per kg of solvent, g per dL (100mL) of solvent, molarity, molality, mole fraction or other similar descriptions of concentration.
Density
            Density is the measure of the mass per unit volume of a material (density = mass/volume). Density is a characteristic of a substance. Mass and volume vary with size but density will remain constant. Temperature will affect the density of a substance.

 Molarity
            A useful way to express exact concentrations of solutions is molarity. Molarity is defined as moles of solute per litre of solution. Molarity is symbolized by the capital letter M. It can be expressed mathematically as follows.

Molarity (M)   =          moles of solute (n)
Liters of solution (V)

            Notice that the moles of solute are divided by the liters of solution not solvent. One litre of one molar solution will consist of one mole of solute plus enough solvent to make a final volume of one litre.

Normality
            The normal concentration is another method for expressing the concentration of solutions.
            Normality (N) is defined as the number of equivalents of solute dissolved in one litre of solution.
            One equivalent of acid is the amount of acid necessary to give up one mole of hydrogen ions in a chemical reaction. One equivalent of base is the amount of base that reacts with one mole of hydrogen ions. When expressing the concentrations of bases, normality refers to the number of available hydroxyl ions. Because hydrogen and hydroxyl ions combine on a one-to-one basis, one OH- is equivalent to one H+ ion.

            ppm expresses the concentration of a solution in units of one part of solute to one million parts solvent. One ppm equals one milligram of solute per litre of solution.

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