Pharm. Inorganic chem_syllabus

BP104T. PHARMACEUTICAL INORGANIC CHEMISTRY (Theory)

45 Hours

Scope: This subject deals with the monographs of inorganic drugs and pharmaceuticals.

Objectives: Upon completion of course student shall be able to

· know the sources of impurities and methods to determine the impurities in inorganic drugs and pharmaceuticals

· understand the medicinal and pharmaceutical importance of inorganic compounds

Course Content:

UNIT I                                                                                                   10 Hours

Impurities in pharmaceutical substances: History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate

General methods of preparation, assay for the compounds superscripted with asterisk (*),    properties and medicinal uses of inorganic compounds belonging to the following classes

UNIT II                                                                                                    10 Hours

·       Acids, Bases and Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.

·       Major extra and intracellular electrolytes: Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration Salt (ORS), Physiological acid base balance.

·       Dental products: Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

UNIT III                                                                                                    10 Hours

·       Gastrointestinal agents

·       Acidifies: Ammonium chloride* and  Dil. HCl

·       Antacid:  Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture

·       Cathartics: Magnesium sulphate, Sodium orthophosphate, Kaoline and Bentonite

·       Antimicrobials: Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations.

UNIT IV                                                                                                    08 Hours

·       Miscellaneous compounds

• Expectorants: Potassium iodide, Ammonium chloride*.

• Emetics: Copper sulphate*, Sodium potassium tartarate

• Haematinics: Ferrous sulphate*, Ferrous gluconate
• Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrate

• Astringents: Zinc Sulphate, Potash Alum

UNIT V                                                                                               07 Hours

Radiopharmaceuticals: Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes - Sodium iodide I¹²¹, Storage conditions, precautions & pharmaceutical application of radioactive substances.

BP110P. PHARMACEUTICAL INORGANIC CHEMISTRY (Practical)

                                                                                                      4 Hours / Week

I	Limit tests for following ions 1.     Limit test for Chlorides and Sulphates 2.     Modified limit test for Chlorides and Sulphates 3.     Limit test for Iron 4.     Limit test for Heavy metals 5.     Limit test for Lead 6.     Limit test for Arsenic
II	Identification test 1.     Magnesium hydroxide 2.     Ferrous sulphate 3.     Sodium bicarbonate 4.     Calcium gluconate 5.     Copper sulphate
III	Test for purity 1.     Swelling power of Bentonite 2.     Neutralizing capacity of aluminum hydroxide gel 3.     Determination of potassium iodate and iodine in potassium Iodide
IV	Preparation of inorganic pharmaceuticals 1.     Boric acid 2.     Potash alum 3.     Ferrous sulphate

Recommended Books (Latest Editions)

1.           A.H. Beckett & J.B. Stenlake's, Practical Pharmaceutical Chemistry Vol I & II, Stahlone Press of University of London, 4^th edition.

2.           A.I. Vogel, Text Book of Quantitative Inorganic analysis

3.           P. Gundu Rao, Inorganic Pharmaceutical Chemistry, 3^rd Edition

4.           M.L Schroff, Inorganic Pharmaceutical Chemistry

5.           Bentley and Driver's Textbook of Pharmaceutical Chemistry

6.           Anand & Chatwal, Inorganic Pharmaceutical Chemistry

7.           Indian Pharmacopoeia